Archive - Latent.Space

🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik

95% of cancer treatments fail to pass clinical trials, but it may be a matching problem — that Noetik is solving with autoregressive transformers like…

16 hrs ago • Brandon Anderson, RJ Honicky, and Latent.Space

1:25:21

Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion

Notion's cofounder and head of AI peel back the curtains to talk about finally shipping the Knowledge Work AI agents the world has been waiting for.

Apr 15

1:17:17

Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier …

We shed light on OpenAI's first Dark Factory for the first time.

Apr 7

1:12:42

Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"

The legend needs no intro... if you pardon our pun

Apr 3

1:16:19

Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun

We cap out our World Models coverage with one of the most exciting new approaches - long running, multiplayer, interactive world models built with…

Apr 2

1:06:47

March 2026

Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample

Mistral is one of the world's leading frontier model labs, and has just launched Voxtral TTS, their latest step in their strategy to offer open frontier…

Mar 30

48:47

🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik

Lessons from a Decade on the Frontier of AI for Science

Mar 24 • Brandon Anderson and RJ Honicky

35:14

Dreamer: the Personal Agent OS — David Singleton

/dev/agents is out of stealth as Dreamer, and the vision is staggeringly ambitious.

Mar 20

1:03:35

Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop

Claude Cowork came out of an accident.

Mar 17

1:26:59

Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer

Turbopuffer came out of a reading app.

Mar 12

1:00:32

NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)

NVIDIA welcomes AI Engineers with a special pre GTC episode!

Mar 10

1:23:37

Cursor's Third Era: Cloud Agents

The $50B Agent Lab has acquired Graphite and Autotab and now announcing that Cloud Agents has overtaken its historical "VSCode fork" IDE usecase…

Mar 6

1:06:38

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